Exclusions set on a host cannot be cleared by the Huntress agent, so if you see a "Source: Host" exclusion making your agent non-compliant in Managed AV (Microsoft Defender) you'll need to manually remove them to become compliant again.
Open up Windows Security Center (click on the start button and type "Windows Security Center")
Click on Virus & threat protection
Click on Manage Settings
Scroll down and click on Add or remove exclusions
For each exclusion you wish to remove move your mouse over the exclusion until a down arrow appears, click on that, then click the Remove button that appears